Domenico Accili Selected Research

Insulin Receptor

1/2020	Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.
1/2019	Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons.
5/2013	Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance.
3/2013	Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice.
11/2011	Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.
3/2011	Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes.
3/2011	Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.
4/2010	The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia.
1/2010	The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression.
8/2007	Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice.

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Domenico Accili Research Topics

Disease

48	Insulin Resistance 11/2021 - 01/2002
22	Type 2 Diabetes Mellitus (MODY) 01/2022 - 05/2002
13	Hyperglycemia 01/2022 - 10/2003
10	Obesity 01/2020 - 10/2002
8	Atherosclerosis 01/2016 - 03/2004
7	Glucose Intolerance 01/2022 - 10/2002
7	Hyperinsulinism (Hyperinsulinemia) 01/2018 - 10/2002
6	Inflammation (Inflammations) 01/2016 - 09/2005
5	Hypoglycemia (Reactive Hypoglycemia) 01/2019 - 09/2005
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 04/2010
4	Atherosclerotic Plaque (Atheroma) 01/2016 - 04/2006
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2014 - 03/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 03/2012
3	Body Weight (Weight, Body) 10/2013 - 10/2008
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 01/2015
2	Weight Gain 01/2021 - 11/2011
2	Weight Loss (Weight Reduction) 01/2017 - 10/2009
2	Thinness 11/2015 - 06/2012
2	Neoplasms (Cancer) 06/2015 - 11/2007
2	Dyslipidemias (Dyslipidemia) 04/2012 - 01/2012
2	Ketosis 05/2005 - 01/2003
2	Perinatal Death 05/2005 - 07/2004
1	Type 1 Maturity-Onset Diabetes of the Young 11/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Uremia 01/2021
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2020
1	Cytokine Release Syndrome 11/2020
1	COVID-19 11/2020
1	Anorexia 02/2015
1	Fatty Liver 08/2013
1	Leukocytosis (Pleocytosis) 03/2013
1	Disease Progression 03/2011
1	Hypoxia (Hypoxemia) 03/2010

Drug/Important Bio-Agent (IBA)

46	Insulin (Novolin)FDA Link 01/2020 - 01/2002
30	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2002
20	Insulin ReceptorIBA 01/2020 - 01/2003
12	LipidsIBA 11/2021 - 09/2006
8	Transcription Factors (Transcription Factor)IBA 11/2021 - 09/2005
5	Sirtuin 1IBA 06/2015 - 09/2005
5	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 03/2013 - 10/2002
3	LeptinIBA 11/2015 - 04/2010
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2013 - 10/2009
3	oxidized low density lipoproteinIBA 04/2012 - 04/2009
3	Proteins (Proteins, Gene)FDA Link 12/2011 - 09/2005
3	AdiponectinIBA 10/2008 - 07/2004
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2019 - 06/2011
2	Blood Glucose (Blood Sugar)IBA 01/2018 - 03/2011
2	CholesterolIBA 01/2016 - 12/2011
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2016 - 10/2009
2	ProinsulinIBA 01/2015 - 10/2002
2	Bile Acids and Salts (Bile Acids)IBA 12/2013 - 01/2012
2	Sirolimus (Rapamycin)FDA Link 08/2013 - 08/2003
2	Protein Isoforms (Isoforms)IBA 05/2013 - 03/2012
2	LDL CholesterolIBA 04/2012 - 12/2010
2	LDL Receptors (LDL Receptor)IBA 03/2012 - 04/2009
2	Triglycerides (Triacylglycerol)IBA 01/2012 - 03/2011
2	CarbohydratesIBA 06/2011 - 09/2006
2	Insulin-Like PeptidesIBA 03/2010 - 09/2002
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 02/2010 - 10/2009
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	Lipoproteins (Lipoprotein)IBA 11/2021
1	A-factor (Streptomyces)IBA 11/2020
1	Vitamin D FDA LinkGeneric 11/2020
1	Leukotriene B4IBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA 01/2020
1	Rosiglitazone (Avandia)FDA Link 01/2017
1	PhlorhizinIBA 01/2017
1	IncretinsIBA 04/2016
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2016
1	stearoyl-coenzyme A (stearoyl-CoA)IBA 06/2015
1	EnzymesIBA 06/2015
1	C-PeptideIBA 01/2015
1	Cholinergic ReceptorsIBA 07/2014
1	Deoxycholic Acid (Sodium Deoxycholate)IBA 12/2013
1	Cholic AcidIBA 12/2013
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 10/2013
1	TOR Serine-Threonine KinasesIBA 08/2013
1	Mechanistic Target of Rapamycin Complex 1IBA 08/2013
1	Tyrosine (L-Tyrosine)FDA Link 05/2013
1	AntioxidantsIBA 03/2013
1	Acetylcysteine (Siran)FDA LinkGeneric 03/2013
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 05/2012
1	Streptozocin (Streptozotocin)FDA Link 03/2012
1	Superoxides (Superoxide)IBA 03/2012
1	VLDL LipoproteinsIBA 01/2012
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2011
1	MitogensIBA 12/2011
1	CytokinesIBA 11/2011
1	Insulin Receptor Substrate ProteinsIBA 11/2011
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2011
1	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 07/2011
1	AdipokinesIBA 04/2010

Therapy/Procedure

4	Therapeutics 05/2015 - 04/2010
2	Peritoneal Dialysis 01/2021 - 01/2015
1	Renal Dialysis (Hemodialysis) 01/2021
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020
1	Glycemic Control 01/2020
1	Traction 04/2010